ADAP drugs: triple sulfa

triple sulfa
(Dayto Sulf, Gyne-Sulf, Sultrin, Trysul, VVS)

Drug description
Triple sulfa is a combination of drugs from the class of drugs called sulfonamides used in combination to treat a variety of infections. At one time sulfonamides were widely used in the treatment and prevention of infections such as urinary tract infections, chlamydia, rheumatic fever, toxoplasmosis and malaria. The development of resistance in many of these organisms has greatly limited the clinical usefulness of these drugs.

Side effects
Adverse effects of the sulfonamides are numerous and may involve nearly all organ systems. Some of the side effects include hypersensitivity, rash, intense itching of the skin, photosensitivity, high fever, severe headache, inflammation of the mouth, liver damage, kidney damage, nausea, vomiting, abdominal pain, anorexia, diarrhea, GI bleeding, headache, dizziness, mental depression, hallucinations, confusion, seizures, ringing in the ears, drowsiness, restlessness and insomnia.

Dosage
Sulfonamides are given orally or intravaginally. Dosage should be determined individually according to the severity of the infection, the drug being used, and the response and tolerance of the patient. The usual dosage of triple sulfa cream for intravaginal administration is one full applicator of vaginal cream twice daily for 4-6 days. Dosage may then be decreased to 1/2 to 1/4 of an full applicator twice daily. Alternatively, one triple sulfa vaginal tablet may be inserted before going to bed and in the morning for 10 days. A second course of treatment may be necessary.

How long it may take to work
For vaginal infections, treatment is 10 days. Prolonged therapy for up to 6 months or longer is necessary for treatment of toxoplasmosis in people with AIDS.

Managing side effects
Wear protective clothing and avoid prolonged exposure to sunlight. If rash or photosensitivity develop, the drug should be stopped at once.

This information is specific to the use of this medication for HIV-related conditions. For additional information about this drug for other conditions, refer to: www.nursespdr.com/ and www.healthanswers.com/Library/library_fset.asp

The drug descriptions on these pages are intended for informational purposes only. The Network does not promote or endorse the use of any specific treatment for any health-related condition. The medications described here can only be dispensed by a licensed health care professional. The information may have changed since these pages were updated, though every effort is made to keep these pages current. Please contact The Network at (800) 734-7104 to make sure you have the most up-to-date information

To drug index To Access Project home page