Immune Based Therapies (IBTs)
Drug Development Pipeline2004

Cytokines and Immunomodulators • Therapeutic Vaccines • Gene Therapies • Cellular Therapies

See also: Shot in the Dark: IBT Pipeline 2004

IBTs in Development
Information on IBT in development is ever-changing. If you know of any inaccuracies in—or omissions from—this list, please send an e-mail to richard.jefferys@verizon.net

Cytokines and Immunomodulators

ProductManufacturerStatus
interleukin-2 (IL-2)ChironPhase III
BAY 50-4798BayerPhase I/II
interleukin-7 (IL-7)Biotech Inflection PointPreclinical
Interleukin-15 (IL-15)Amgen (formerly Immunex)Preclinical
IL-4/IL-13 trapRegeneron PharmaceuticalsPhase I
Serostim (human growth hormone)SeronoPhase not specified (ACTG 5174)
TucaresolGlaxoSmithKlinePhase I
MDX-010 anti-CTLA4 antibodyMedarexPhase I
Avrend (CD40 ligand)Amgen (formerly Immunex)?
Pegasys (peginterferon alfa-2a)Roche PharmaceuticalsPhase IB/II
HE2000Hollis EdenPhase II?
HRG214 passive immunotherapyVirionyx Corporation LtdPhase I/II

Therapeutic Vaccines

ALVAC (vCP1452)Aventis PasteurPhase II
LipopeptidesAventis Pasteur/ANRSPhase II
DermavirResearch Institute for Genetic & Human Therapy (RIGHT)Preclinical
VRC-HIVDNA009-00-VP Gag/Pol/Nef/multiclade Envs (A, B, C)VRC/NIAIDPhase I
MVA-BN-NefBavarian NordicPhase I
MVA-mBN32Bavarian Nordic/EpimmunePhase I
MRKAd5MerckPhase I/II
MRKDNAMerckPhase I
VEE repliconAlphaVaxPhase I in HIV seronegative volunteers
Autologous dendritic cells pulsed w/ALVACACTG/AventisPhase I
Autologous dendritic cell HIV vaccination w/conserved HIV-derived peptidesUniversity of PittsburghPhase I
Multi-epitope DNAEpimmunePhase I
DNA + IL-12 or IL-15Wyeth-AyerstPreclinical
Whole-killed (pseudovirions)Kathy Grovit-Ferbas/UCLAPreclinical
HIVAXGlobeimmunePreclinical
Tat/Nef/gp120 in ASO2A adjuvantGlaxoSmithKlinePreclinical
DNA/MVACobra Pharmaceuticals, Impfstoffwerk Dessau-Tornau GmbH (IDT), Oxford University/MRCPhase I/II
RemuneImmune Response CorporationFailed phase III, remains under investigation in context of STIs
Tat vaccineAventis PasteurPhase I
DNA/fowlpox prime-boostViraxPhase I
Synthetic peptide immunogensUnited BiomedicalPreclinical
HIV L.E.A.P.S. HIV-1 p17 constructs (L.E.A.P.S. 101B, 101C, 102B and 102C)Cel-SciPreclinical
GTU-Nef DNA vaccineFIT-BIOTECHPhase I
Autologous Delipidated HIV Therapeutic VaccineLipid SciencesPreclinical

Gene Therapies

VRX496 lentiviral vectorVIRxSYSPhase I
Ribozymes (RRz2)Johnson & JohnsonPhase II
HGTV43Enzo BiochemPhase I
CD4 T cells transduced with M87o viral entry inhibitorEUFETS AGPhase I
CD4zeta modified CD4 and CD8 T cellsCell GenesysPhase II

Cellular Therapies

Activated Cellular Therapy (ACT)NeoprobeOn hold pending identification of a development partner


Basic Science Index IBT Pipeline 2004
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