ADAP drugs: methotrexate

methotrexate
(Amethopetrin, Folex, Folex PFS)

Drug description

Methotrexate is used alone or in combination with chemotherapies, surgery or radiation for treatment of cancers, lymphomas, leukemias, rheumatoid arthritis, and severe psoriasis.

Side effects
Treatment with methotrexate, as with other chemotherapy agents, can have many side effects such as upset stomach, nausea, vomiting, liver toxicity, anemia, leukopenia, and thrombocytopenia. Some drugs, such as anti-inflammatory agents and acyclovir, can increase the toxicity of methotrexate.

Dosage
Dosage reduction is required if you have any kidney impairment. Treatment is by mouth, intramuscular or intravenous injection, or injection into the spine. Dosage depends on the condition being treated.

How long it may take to work
Effectiveness of treatment can be seen in improvement of blood markers in leukemia, decrease in size and spread of non-Hodgkin’s lymphomas and other solid cancers, resolution of skin lesions in severe psoriasis, decreased joint pain and swelling, and improved mobility if you are being treated for rheumatoid arthritis.

Managing side effects
Drink at least 2 quarts of high calorie fluids such as juices and nectars per day. If treatment is in pill form, take 1 hour before or 2 hours after meals. Report any unusual bleeding to your doctor. Use a soft toothbrush and electric razor. Do not drink alcoholic beverages or take drugs containing aspirin. Avoid use of over-the-counter drugs without first consulting with your doctor or pharmacist. Contraception should be practiced during and for at least 8 weeks after completion of therapy.

This information is specific to the use of this medication for HIV-related conditions. For additional information about this drug for other conditions, refer to: www.nursespdr.com/ and www.healthanswers.com/Library/library_fset.asp

The drug descriptions on these pages are intended for informational purposes only. The Network does not promote or endorse the use of any specific treatment for any health-related condition. The medications described here can only be dispensed by a licensed health care professional. The information may have changed since these pages were updated, though every effort is made to keep these pages current. Please contact The Network at (800) 734-7104 to make sure you have the most up-to-date information

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